McMaster Researchers Discover Promising New Antibiotic for Crohn’s disease with Help from AI

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Hamilton Business Review

October 9, 2025
Scientists wearing lab coats in a lab.

‘”Researchers at McMaster University and the Massachusetts Institute of Technology (MIT) have made two scientific breakthroughs at once: They not only discovered a brand-new antibiotic that targets inflammatory bowel diseases (IBD), but also used a new type of AI to successfully predict exactly how the drug works. To their knowledge, this a global first for the AI.

Detailed Oct. 3 in the journal Nature Microbiology, the discovery unveils a promising new treatment option for millions of people affected by Crohn’s disease and related conditions, while also showcasing important new applications for AI in drug discovery research.

‘This work shows that we’re still just scratching the surface as far as AI-guided drug discovery goes,’ says Jon Stokes, an assistant professor in McMaster’s Department of Biochemistry and Biomedical Sciences, and principal investigator on the new study.

‘The development of our new drug, which is designed to target IBD, has been fast-tracked thanks to the collaboration between humans and generative AI.”

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